Fig. 4

GSEA analysis of key genes. (A–F) The KEGG signaling pathways involved in the key genes, as well as the pathway regulation and the genes involved. KEGG is developed by Kanehisa Laboratories. Reference: Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y. and Ishiguro-Watanabe, M.; KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53, D672-D677 (2025). https://doi.org/10.1093/nar/gkae909.