Fig. 1

Scheme of TTR minimal model, showing the transitions for homotetramers and monomers together with corresponding rates (described in the main text). Possible effects, direct and indirect, of action of tetramer stabilisers are denoted as ([Drug]?), while the known stabilisers’ effect on tetramer dissociation rate is denoted as \(k_{d} \left( {\left[ {Drug} \right]} \right)\).