Table 3 The independent effect of uric acid measures in first trimester of gestation on the risk of primary and secondary outcome.

From: Elevated serum uric acid before 20 weeks of gestation increases the risk of preeclampsia

Exposure

Model I

Model II

OR (95% CI)

P value

OR (95% CI)

P value

Primary outcome

PE

<240 (µmol/L)

Reference

 

Reference

 

240~360 (µmol/L)

1.75 (1.61–1.91)

<0.0001

1.15 (1.04–1.28)

0.0084

≥360 (µmol/L)

6.03 (4.73–7.69)

<0.0001

1.74 (1.23–2.48)

0.0018

Continuous UA per 50 µmol/L

1.48 (1.43–1.54)

<0.0001

1.14 (1.09–1.20)

<0.0001

Continuous UA per 100 µmol/L

2.20 (2.04–2.37)

<0.0001

1.31 (1.19–1.45)

<0.0001

Secondary outcome

Preterm birth

<240 (µmol/L)

Reference

 

Reference

 

240~360 (µmol/L)

1.56 (1.43–1.70)

<0.0001

1.45 (1.30–1.61)

<0.0001

≥360 (µmol/L)

3.22 (2.42–4.30)

<0.0001

2.15 (1.46–3.17)

<0.0001

Continuous UA per 50 µmol/L

1.32 (1.27–1.37)

<0.0001

1.24 (1.18–1.30)

<0.0001

Continuous UA per 100 µmol/L

1.73 (1.60–1.87)

<0.0001

1.53 (1.39–1.69)

<0.0001

  1. Model I: None covariates were adjusted;.
  2. Model II: age, BMI, systolic pressure, diastolic pressure, aspirin, depressor, family history of hypertension, tobacco, alcohol, IVF, parity, alanine transaminase, total cholesterol, triglycerides, fasting blood glucose, test week, adverse pregnancy history were adjusted.
  3. UA, uric acid; PE, preeclampsia; OR, odds ratio; CI, confidence interval.
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