Table 4 Subgroup analysis for the association between UA and PE.

From: Elevated serum uric acid before 20 weeks of gestation increases the risk of preeclampsia

PE

Odds Ratio

(95% CI)

P value

P for interaction

Adjust Odds Ratio (95% CI)

P value

P for interaction

Age (years)

  

0.6251

  

0.2129

Age < 35

<240 (µmol/L)

Reference

  

Reference

  

240~360 (µmol/L)

1.75 (1.59–1.93)

<0.0001

 

1.19 (1.05–1.34)

0.0047

 

≥360 (µmol/L)

5.61 (4.22–7.45)

<0.0001

 

1.61 (1.07–2.40)

0.0212

 

Age ≥ 35

<240 (µmol/L)

Reference

  

Reference

  

240~360 (µmol/L)

1.74 (1.46–2.08)

<0.0001

 

1.02 (0.81–1.29)

0.8468

 

≥360 (µmol/L)

7.35 (4.57–11.84)

<0.0001

 

2.26 (1.09–4.68)

0.0283

 

BMI (kg/m2)

  

0.9704

  

0.0234

BMI < 24

<240 (µmol/L)

Reference

  

Reference

  

240~360 (µmol/L)

1.45 (1.29–1.62)

<0.0001

 

1.21 (1.06–1.38)

0.0050

 

≥360 (µmol/L)

3.99 (2.54–6.28)

<0.0001

 

2.33 (1.33–4.09)

0.0032

 

BMI ≥ 24

<240 (µmol/L)

Reference

  

Reference

  

240~360 (µmol/L)

1.46 (1.26–1.68)

<0.0001

 

1.07 (0.90–1.27)

0.4681

 

≥360 (µmol/L)

3.74 (2.71–5.16)

<0.0001

 

1.55 (1.00–2.42)

0.0497

 

Parity

  

0.1685

  

0.5051

Primipara

<240 (µmol/L)

Reference

  

Reference

  

240~360 (µmol/L)

1.77 (1.61–1.95)

<0.0001

 

1.15 (1.02–1.29)

0.0218

 

≥360 (µmol/L)

5.42 (4.04–7.26)

<0.0001

 

1.58 (1.07–2.34)

0.0226

 

Multipara

<240 (µmol/L)

Reference

  

Reference

  

240~360 (µmol/L)

1.70 (1.40–2.07)

<0.0001

 

1.15 (0.89–1.49)

0.2843

 

≥360 (µmol/L)

8.94 (5.68–14.06)

<0.0001

 

2.66 (1.20–5.91)

0.0161

 
  1. Adjusted for age, BMI, systolic, diastolic,aspirin, depressor, family history of hypertension, tobacco, alcohol, IVF, parity, alanine transaminase, total cholesterol, triglycerides, fasingt blood glucose, test week, adverse pregnancy history.
  2. UA, uric acid; PE, preeclampsia; CI, confidence interval; BMI, body mass index.
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