Table 1 Baseline patient characteristics in the patients with acute exacerbations of chronic obstructive pulmonary disease.
From: Platelet count has a U-shaped association with all-cause mortality in COPD patients
Overall (n = 853) | Platelet count <150 × 109/L (n = 154) | Platelet count ≥ 150 × 109/L to < 300 × 109/L (n = 605) | Platelet count ≥300 × 109/L (n = 94) | P-value | |
|---|---|---|---|---|---|
Age, y | 71.39 ± 10.18 | 73.38 ± 8.68 | 70.93 ± 10.45 | 71.09 ± 10.41 | 0.108 |
Male gender | 501(58.7) | 100(64.9) | 362(59.8) | 39(41.5) | 0.001 |
BMI | 21.30 ± 3.52 | 21.33 ± 2.95 | 21.39 ± 3.64 | 20.66 ± 3.60 | 0.173 |
smoking history | 293(34.3) | 57(37) | 216(35.7) | 20(21.3) | 0.018 |
COPD history, y | 10.00(6.00,20.00) | 10.00(6.00,20.00) | 10.00(6.00,20.00) | 10.00(6.75,20.00) | 0.906 |
Diabetes mellitus | 76(8.9) | 15(9.7) | 51(8.4) | 10(10.6) | 0.723 |
hypertension | 302(35.4) | 52(33.8) | 224(37.0) | 26(27.7) | 0.189 |
CKD | 12(1.4) | 2(1.3) | 9(1.5) | 1(1.1) | 0.941 |
Atrial fibrillation | 51(6.0) | 23(14.9) | 25(4.1) | 3(3.2) | < 0.001 |
CAD | 131(15.4) | 26(16.9) | 93(15.4) | 12(12.8) | 0.684 |
NYHA class III/IV symptoms | 264 (30.9) | 72(46.8) | 171(28.3) | 21(22.3) | < 0.001 |
Malignant tumor | 23(2.7) | 3(1.9) | 17(2.8) | 3(3.2) | 0.800 |
Hyperlipidemia | 102(12.0) | 9(5.8) | 80(13.2) | 13(13.8) | 0.035 |
Antiplatelet | 81(9.5) | 15(9.7) | 60(9.9) | 6(6.4) | 0.550 |
Lipid-lowering drugs | 164(19.2) | 24(15.6) | 125(20.7) | 15(16.0) | 0.251 |
Anticoagulation | 73(8.6) | 19(12.3) | 47(7.8) | 7(7.4) | 0.179 |
Bronchodilators | 781(91.6) | 141(91.6) | 551(91.1) | 89(94.7) | 0.505 |
ICS | 773(90.6) | 139(90.3) | 547(90.4) | 87(92.6) | 0.792 |
Antibiotic | 759(89.0) | 134(87.0) | 535(88.4) | 90(95.7) | 0.075 |
FEV1 | 54.36 ± 20.37 | 53.53 ± 16.93 | 54.18 ± 21.12 | 56.70 ± 20.44 | 0.744 |
FEV1/FVC,% | 47(47,56) | 49(40,59) | 47(44,55) | 51(42,61) | 0.172 |
FBG, g/l | 5.25(4.71,6.22) | 5.32(4.64,6.45) | 5.25(4.73,6.23) | 5.12(4.67,5.97) | 0.514 |
PT, s | 11.30(10.60,12.10) | 11.70(10.80,12.60) | 11.10(10.50,12.00) | 11.40(10.60,12.40) | < 0.001 |
INR | 0.97(0.91,1.05) | 1.02(0.93,1.10) | 0.96(0.91,1.04) | 0.98(0.92,1.08) | < 0.001 |
PTA,% | 95.60(82.50,108.10) | 89.40(76.30,89.40) | 97.30(85.20,108.90) | 94.00(79.60,106.20) | < 0.001 |
APTT, s | 27.00(24.80,29.30) | 28.15(25.20,31.03) | 26.80(24.75,28.95) | 26.45(24.50,28.23) | < 0.001 |
D-D, md/l | 0.57(0.31,1.27) | 0.70(0.33,1.79) | 0.52(0.29,1.06) | 0.73(0.40,1.59) | < 0.001 |
ALB, g/l | 36.20(32.85,39.75) | 35.75(32.40,38.60) | 36.70(33.60,40.20) | 33.45(29.05,37.70) | < 0.001 |
ALT, u/l | 15.00(11.00,22.00) | 17.00(12.75,25.00) | 15.00(11.00,22.00) | 14.00(10.00,22.00) | 0.017 |
AST, u/l | 21.00(16.00,27.00) | 24.00(19.00,33.00) | 20.00(16.00,27.00) | 20.00(14.00,26.00) | < 0.001 |
BUN, mmol/l | 6.49 (4.89,8.54) | 7.26(5.52,9.33) | 6.39(4.89,8.45) | 5.98(3.99,8.04) | < 0.001 |
sCr, umol/l | 67.00(56.00,82.00) | 73.35(59.90,91.18) | 66.00(55.60,81.25) | 63.20(52.75,74.85) | < 0.001 |
BNP, pg/ml | 284.80(130.50,1021.60) | 529.20(204.10,2621.53) | 271.30(120.90,826.40) | 222.70(120.18,494.75) | < 0.001 |
TG, mmol/l | 0.97(0.78,1.32) | 0.93(0.76,1.19) | 0.97(0.78,1.33) | 1.11(0.86,1.43) | 0.006 |
TC, mmol/l | 4.25(3.58,5.06) | 3.84(3.17,4.64) | 4.36(3.68,5.16) | 4.07(3.49,5.27) | < 0.001 |
LDL-C, mmol/l | 2.28(1.84,2.87) | 1.94(1.59,2.35) | 2.34(1.93,2.93) | 2.45(1.92,3.12) | < 0.001 |
hs-CRP, mg/l | 13.71(3.22,58.60) | 13.90(2.87,47.28) | 10.57(2.79,52.60) | 34.64(9.25,73.98) | 0.001 |
WBC,× 109/L | 7.70(5.80,10.30) | 6.25(4.80,8.43) | 7.70(6.00,10.20) | 9.95(7.68,12.73) | < 0.001 |
Hb, g/l | 134.00(123.00,146.00) | 136.00(125.00,150.00) | 135.00(123.00,146.00) | 124.50(111.00,135.25) | < 0.001 |
PCO2,mmHg | 42.20(37.90,49.10) | 43.15(38.18,52.33) | 42.20(37.56,48.01) | 41.10(38.60,47.75) | 0.125 |
