Table 1 Box-Benhken Response Surface methodology experimental design program and results.

From: CKAAKN peptide-conjugated long-circulating nanoliposomes for the targeted delivery of oridonin to pancreatic cancers

Number

X1/mg

X2/%

X3/min

Y/%

1

60(0)

8(+ 1)

30(-1)

75.1112

2

60

7(0)

45(0)

98.5979

3

60

7

45

96.9858

4

40(-1)

6(-1)

45

86.062

5

80(+ 1)

6

45

78.1221

6

40

8

45

86.3754

7

80

8

45

81.3881

8

60

6

60(+ 1)

88.083

9

60

8

60

79.6506

10

80

7

60

83.7353

11

60

7

45

98.3404

12

60

7

45

92.5446

13

80

7

30

79.5635

14

40

7

60

86.5116

15

60

7

45

95.92

16

40

7

30

85.0659

17

60

6

30

87.0452

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