Fig. 1
a Quantitative DCE-MRI Parameters Analysis of Tibial Bone in T1DM Rabbits. Red circles: Metaphyseal region of interest (ROI); Yellow circles: Diaphyseal ROI. Ktrans: Volume transfer constant; Kep: Rate constant; Ve: Extravascular extracellular volume fraction. b Estimated marginal means of DCE-MRI parameters (Ktrans, Kep, Ve) in bone marrow of T1DM and control rabbits. Error bars represent 95% confidence intervals. T1DM rabbits showed significantly higher values than controls for all parameters (all p < 0.001). Within the T1DM group, metaphyseal regions exhibited significantly elevated values compared to diaphyseal regions (all p < 0.001), a pattern not observed in controls. Statistical analyses were performed using linear mixed-effects models with Tukey-adjusted post-hoc tests. c USPIO-Enhanced MRI of Metaphysis and Diaphysis in T1DM and Control Rabbits. Red circles: Metaphysis; Black circles: Diaphysis. T1DM bone marrow demonstrated significantly increased T2 changes compared to controls (P < 0.05). d Temporal T2 Change Curves from USPIO-Enhanced MRI in T1DM and Control Rabbits. T1DM metaphysis showed significantly higher maximum T2 value and maximum T2 change rate than diaphysis (P < 0.05), whereas no significant differences were observed between metaphyseal and diaphyseal regions in controls (P > 0.05). e. Estimated marginal means of USPIO-enhanced MRI parameters (maximum T2 change and T2 change rate) in bone marrow of T1DM and control rabbits. Error bars represent 95% confidence intervals. T1DM rabbits showed significantly higher values than controls for both parameters (both p < 0.001). Within the T1DM group, metaphyseal regions exhibited significantly elevated values compared to diaphyseal regions (both p < 0.001), a pattern not observed in controls.
