Table 2 Antibiotic Resistance Profiles of MDR K. pneumoniae Isolates (n = 30).

From: Integrated analysis of global regulators and efflux genes associated with antimicrobial resistance reversal in multidrug resistant Klebsiella pneumoniae

Antibiotic Class

Agent(s)

Resistance in MDR Isolates

MIC (MDR Isolates)

MIC (Control Isolates)

Notes

Fluoroquinolones

Ciprofloxacin

100% (30/30)

8 – > 64 µg/mL

 ≤ 0.5 µg/mL

No/ ≤ 15 mm zone in disk diffusion

Aminoglycosides

Gentamicin

100% (30/30)

8 – 32 µg/mL

 ≤ 2 µg/mL

Markedly elevated MICs

3rd Gen Cephalosporins

CTX / CAZ

90% (27/30)

Resistant (not specified)

 ≤ 1 µg/mL

Confirmed ESBL phenotype via synergy tests

Carbapenems

Imipenem / Meropenem

20% (6/30)

 ≥ 16 µg/mL

 ≤ 1 µg/mL

Suggests the presence of carbapenemases

Folate Inhibitors & Tetracyclines

TMP-SMX

100% (30/30)

Not specified

 ≤ 0.5 µg/mL

Universally resistant

 

Tetracycline

100% (30/30)

Not specified

 ≤ 2 µg/mL

Universally resistant

  1. CTX, Cefotaxime; CAZ, Ceftazidime; IPM, Imipenem; MEM, Meropenem; TMP-SMX, Trimethoprim-Sulfamethoxazole; MIC, Minimum Inhibitory Concentration; MDR, Multidrug-resistant.
  2. “Not specified” indicates that MIC testing for these antibiotics was not performed. Statistical significance was defined using Bonferroni correction for six comparisons (α = 0.05/6 ≈ 0.0083).