Fig. 5
The metabolic profiles are altered in TRMT6-deficient mice. (A) Volcano plot showing dysregulated known metabolites in small intestine of Trmt6−/− vs. Trmt6+/+ mice. KO, Trmt6−/−; WT, Trmt6+/+. (B) Heatmap showing dysregulated known metabolites in small intestine of Trmt6−/− vs. Trmt6+/+ mice. KO, Trmt6−/−; WT, Trmt6+/+. (C) Bar graphs showing the fraction (left) and count (right) of dysregulated known metabolites in each class in small intestine of Trmt6−/− vs. Trmt6+/+ mice. Color indicates direction of changes. (D) Box plot comparing the changes in plasma of the metabolites grouped by their changes in small intestine. (E) Venn plot (top left) showing overlap between differentially regulated metabolites in intestine and plasma, and scatter plot showing the changes of the overlapped metabolites in intestine and plasma. Metabolome data are provided in the Supplementary Material 2.
