Table 3 Clinical and laboratory characteristics of participants.

From: Association of ANXA3 methylation with clinical outcomes of glucocorticoid therapy in patients with hepatitis B virus-related acute-on-chronic liver failure

Parameters

GC group (n = 108)

CM group (n = 48)

HCs group (n = 24)

Male, n (%)

83 (76.85)ns

37 (68.52)

17 (70.83)

Age (years)

48 (37–59)ns

50.50 (42.75–56.75)

45.50 (38.75–54.75)

HBsAg (IU/mL)

1096.52 (97.95–5694)ns

483.89 (118.56–1652.89.56.89)

0

HBeAg (IU/mL)

1 (1–3.16.16)ns

2.89 (0.44–100.73.44.73)

0

HBeAg (+), n (%)

66 (61.11)ns

29 (53.70)

0

Log10 [HBV DNA] (IU/mL)

4.59 (3.24–5.76)ns

4.40 (3.21–6.39)

0

HBV DNA (+), n (%)

75 (69.44)ns

32 (59.26)

0

ALT (U/L)

134 (55.25–374.75.25.75)*ns

108.50 (44.50–288.50.50.50)*

20.50 (18–27)

AST (U/L)

126 (74.75–229)*ns

112 (65.75–268)*

20.50 (15–23.75.75)

TBIL (µmol/L)

254.50 (169.83–398.50)*ns

248.65 (148.28–363.08.28.08)*

11.45 (8.75–14.20)

ALB (g/L)

31.90 (29.43–35.43)*ns

32.15 (29.73–35.13)*

46.65 (45.50–49.43.50.43)

Cr (µmol/L)

56 (45–68.75.75)ns

61 (51–79.50.50)

62.50 (56.25–75.50)

PTA (%)

35.50 (29–45.75.75)*ns

42.50 (26–49.50.50)*

110 (98–122)

INR

2.05 (1.67–2.40)*ns

1.80 (1.62–2.78)*

0.95 (0.90–1.01)

PCT (ng/mL)

0.52 (0.35–0.88)ns

0.48 (0.29–1.54)

NA

WBC (10^9/L)

7.27 (5.68–9.82)ns

6.43 (4.61–10.20)

6.41 (5.52–7.66)

NEUT%

72 (63.90–80.28.90.28)*ns

70.05 (56.03–79.85)*

57 (54.48–61.48)

PLT (10^9/L)

102.50 (66.25–158)*ns

103.50 (67.25–135)*

236 (207–266.75.75)

MELD score

19.95 (16.80–23.19.80.19)ns

20.77 (17.54–25.74)

NA

HE, n (%)

25 (23.15)ns

15 (31.25)

0

Ascites, n (%)

68 (63)ns

35 (72.91)

0

mRNA (PPAR-γ)

0.33 (0.23–0.44)*ns

0.27 (0.18–0.40)*

0.51 (0.26–0.71)

mRNA (ANXA3)

0.77 (0.48–1.27)*ns

0.90 (0.54–1.36)*

0.08 (0.03–0.28)

PMR (ANXA3)

11.83 (8.33–15.18)*ns

9.09 (5.81–13.57)*

26.34 (18.92–31.59)

  1. Quantitative variables are expressed as the median (centile 25; centile 75), and Qualitative variables were expressed as numbers (%).
  2. GC: glucocorticoid, CM: conventional medical, HBV-ACLF: hepatitis B virus-related acute-on-chronic liver failure, HCs: healthy controls, HBsAg: hepatitis B virus surface antigen, HBeAg: hepatitis B e antigen, HBV DNA: hepatitis B virus deoxyribonucleic acid, ALT: alanine transaminase, AST: aspartate transferase, TBIL: total bilirubin, ALB: albumin, Cr: creatinine, INR: International normalized ratio, PTA: prothrombin activity, PCT: procalcitonin, WBC: white blood cell, NEUT%: neutrophil ratio, PLT: platelet, HE: hepatic encephalopathy, MELD: model for end-stage liver disease, NA: not available.
  3. ns: GC group vs. CM group, p > 0.05.
  4. *HBV-ACLF patients vs. HCs, p < 0.05.
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