Fig. 1 | Scientific Reports

Fig. 1

From: Multi-omics analysis reveals sevoflurane exacerbates cognitive impairment in diabetic mice by disrupting lipid metabolism

Fig. 1The alternative text for this image may have been generated using AI.

Effects of anesthetics on learning and memory in T1DM mice induced by STZ. (A) Schematic diagram of the experimental timeline. (B) Blood glucose levels at baseline, post-STZ induction, and post-anesthesia (n = 10). (C-E) Mice performance in Morris water maze test (n = 6). (C) Escape latency during training days, (D) number of platform crossings, and (E) time spent in the target quadrant during the probe test. (F) Spontaneous alternation rates in the Y-maze (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 vs CON group; #P < 0.05 vs DM group; @P < 0.05, @@P < 0.01, @@@P < 0.001 vs. DM + PRO group; &&&P < 0.001 vs. DM + SEV group. Data are mean ± SEM. P values were determined by two-way ANOVA followed by Bonferroni’ s multiple comparisons (C, D, F) or Kruskal-Wallis test (B, E)

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