Fig. 5
The spaA genotyping and serotype identification of ERA_01. (a) A schematic representation of the SpaA protein according to Forde et al.27 with discriminatory amino acid positions and amino acid changes they introduce indicated. GW repeats (at a typical number of 8) are shown, additionally, the C-terminal GS motif containing domain is indicated. (b) Results of spaA genotyping of ERA_01 and its close modern relatives using the Forde et al.27 scheme. (c) Serotype-determining region of the ERA_01 genome. The scheme shows the structure of a serotype-determining gene cluster split into three contigs. Contig names and predicted gene products are labeled. Locations of synonymous and non-synonymous SNPs (with amino acid substitutions for the latter labeled) are shown with, respectively, green and red vertical lines.
