Fig. 7
From: Generation of TCRγδ + T cells from human embryonic stem cells
Transcriptome analysis for the mechanism of the differentiation of hESCs into mature γδT cells in vitro. (A) Principal component analysis of γδT cell differentiation. The scatter plot showed the projection of the first two principal components (PC1 and PC2) at different time points. These points represented individual samples and were colored by time points. (B) The bubble plot showed the significantly enriched KEGG pathways identified from upregulated DEGs at days 2, 6, 10, and 25 after the differentiation of hESCs. The y-axis represented KEGG pathway, and the x-axis represented gene ratio. Pathways with p-values < 0.05 were considered significantly enriched. (C–F) PPI networks of up-regulated DEGs among cells from H9 cells to differentiated cells at day 2 (C), day 6 (D), day 10 (E) and day 25 (F) analyzed in STRING database. The KEGG software from the Kanehisa laboratory was used to analyze the data (www.kegg.jp/kegg/kegg1.html).
