Fig. 10
From: LncRNA FTX promotes myocardial fibrosis by sponging miR-335-3p to regulate TFEC/ILK signaling
TFEC silencing reduced fibrosis in ISO-treated mice. (A,B) Immunohistochemical staining results to assess α-SMA and Collagen I expression in heart tissue from ISO-treated mice. (C) Sirius red staining results to visualize collagen fiber deposition in heart tissues of ISO-treated mice. TFEC silencing significantly reduced the expression of α-SMA and Collagen I and Sirius red staining in heart tissues from ISO-treated mice. (D) Representative images of immunohistochemical staining for Collagen I in mouse heart tissues from different groups. (E) Representative images of Sirius Red staining in mouse heart tissues from different groups. (F–K) The results of cardiac function (stroke volume, ejection fraction, and heart rate) in mice. ISO: isoproterenol; shNC: short hairpin RNA negative control; shTFEC: short hairpin RNA against TFEC. *: P < 0.05 between indicated groups.
