Fig. 4
MALAT1 silencing induced an increase in both proliferation/survival and EZH2 expression in MCL PDLS growing without pro-proliferative factors. (A) A noticeable significant downregulation of MALAT1 levels was achieved after 4 days of silencing with a specific Gapmer compared to a scrambled one, in cells from two MCL patients growing only with BAFF (MCL#1 P = 0.0001 and MCL#2 P = 0.0021). (B) MALAT1 silencing induced a significant increase in viability in the two MCL cases (P < 0.0001). (C) EZH2 levels also increased upon MALAT1 silencing, reaching statistical significance in MCL#2 (P < 0.0018). Median values and interquartile range are depicted.
