Fig. 3 | Scientific Reports

Fig. 3

From: MUC14 suppresses lung adenocarcinoma via integrin α8β6/PI3K/AKT/MAPK modulating cisplatin response and immunity

Fig. 3

Tumor-suppressive effects of MUC14-OE in LUAD. (A) Transwell assay showing suppressed migration in MUC14-OE cells under serum starvation after 24 h. (B) Wound healing assay exhibiting delayed wound closure of MUC14-OE cells after 24 h (yellow lines demarcate wound edges). (C,D) Impaired adhesion of extracellular matrix components (fibronectin, collagen I, poly-l-lysine, laminin) in MUC14-OE cells. (E) CCK-8 assay demonstrating reduced proliferation in MUC14-OE cells on day 2–3. (F) MUC14-OE attenuating colony formation capacity in A549 and HCC827 cells. (G–I) MUC14-OE inhibiting subcutaneous tumor growth in BALB/c nude mice (5/5). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; ns, not significant.

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