Fig. 1

Multimodal imaging of a combined hamartomas of the retina and retinal pigment epithelium (CHRRPE) patient A 7-years-old female patient visited our clinic with complaints of gradual decrease in visual acuity of the left eye. Her best corrected visual acuity was 0.397 logMAR. (A) Fundus photography and (B) ultra-widefield fundus photography show a 6.64 mm × 5.50 mm sized elevated mass at peripapillary area. No intraretinal hemorrhage, intraretinal exudation, or pigmentation were noted. (C) On autofluorescence photography, mild hypoautofluorescence was observed at the intraocular mass. (D) On near infrared (NIR) imaging, the mass was isoreflective. The optical coherence tomography (OCT) shows typical elevation and proliferation of retinal layers and the retinal pigment epithelium at the peripapillary area. Posterior vitreous detachment (PVD) is not present. Mild epiretinal membrane (ERM) is noted at nasal to fovea. (E) On B-scan ultrasonography, a slightly hypoechoic mass with height of 1.24 mm was observed at peripapillary location. (F) The foveo-papillary distance (FPD) was calculated from the foveal center to a vessel located at inferior disc margin (red circle). The foveal center was slightly nasally shifted (red asterisk). (G) The central macular thickness (CMT) at 1.0 mm center of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid was 506 μm. The average retinal thicknesses of 3.0 mm inner subfields of ETDRS grid were 786 μm, 394 μm, 513 μm, and 523 μm at nasal, temporal, superior, and inferior, respectively.