Table 1 Microscopic observation for microscopic lesions individual parameters in each group.
Group | Dose | Number of male rats | Observations of microscopic lesions (buccal mucosa) in all treatment groups | ||
|---|---|---|---|---|---|
Discontinuity in mucosal epithelium | Inflammatory cells in connective tissue | Hyperplasia of stratum spinosum | |||
G1 | Normal | 8 | 0/8 | 0/8 | 0/8 |
G2 | Vehicle control | 8 | 71.42% (Moderate) | 85.71% (Mild/Moderate) | 57.14% (Mild/Moderate) |
G3 | Positive control (Placentrex Gel) | 8 | 66.66% (Moderate) | 83.33% (Mild/Moderate) | 66.66% (Mild/Moderate) |
G4 | 5% WHG | 8 | 66.66% (Moderate) | 83.33% (Mild/Moderate) | 33.33% (Mild/Moderate) |
G5 | 10% WHG | 8 | 66.66% (Moderate) | 66.66% (Mild/Moderate) | 66.66% (Mild/Moderate) |
G6 | 15% WHG | 8 | 50% (Minimal) | 0% | 0% |
