Fig. 2 | Scientific Reports

Fig. 2

From: Alternative splicing and differential gene expression during changes in endometrial receptivity in patients with recurrent implantation failure

Fig. 2

Alternative splicing and immune cell analyses between pre-receptive and receptive phases in RIF patients. (A) Analysis of differential ASEs between endometrial PR vs. R phases of HC and RIF (green) patients (orange). The percentage of each type of ASE within each comparison is represented by a pie chart (right) (SE, skipped exon; MXE, mutually exclusive exons; A3SS, alternative 3’ splice site; A5SS, alternative 5’ splice site; RI, retained intron). (B) Venn diagram showing the genes with alternative splicing events in HC: PR vs. R (blue) and RIF: PR vs. R (orange). (C) The proportions of differential ASEs for each type in in HC: PR vs. R (blue) and RIF: PR vs. R (orange). (D) The frequency of possible changes in coding potential shown for SE, MXE, and RI, respectively. (E) Scatter plot displayed the GO analysis of genes with different alternative splicing events. BP: Biological process, CC: cellular component, MF: molecular function. (F) Comparing immune cell distribution between endometrial PR vs. R phase of RIF patients was shown in the boxplot (ns: p > 0.05, * p < = 0.05, ** p < = 0.01, *** p < = 0.001, **** p < = 0.0001). (G) Heatmap of the distribution of immune cells interacting with different ASEs in the endometrial R phases of RIF patients.

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