Table 3 List of 43 overlapping genes with differential alternative splicing events associated with embryo implantation.

1

ACTN1^a,b

a,b

Actinin Alpha 1

Regulation by leukaemia inhibitory factor in uterine luminal epithelial cells

25,031,358

2

AIMP1^a,b

a,b

Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 1

Receptivity associated gene

23,555,582

3

ANXA1^a,b

a,b

Annexin A1

Regulation of steroid hormone secretion; Maintenance of the uterine microenvironment during implantation

32,403,233;29,115,663;22,819,759

4

ANXA2^b

b

Annexin A2

Embryo adhesiveness

22,645,245;33,010,173

5

APOL2^b,d

b,d

Apolipoprotein L2

Decidualization

20,008,415

6

C3^b

b

Complement C3

Genes for endometrial receptivity prediction

20,619,403

7

CD44^a,b

a,b

CD44 molecule (Indian blood group)

Dynamically expressed across the menstrual cycle; Endometrial stromal cell proliferation and decidualization; Embryo adhesion

8,560,955;16,932,025;36,527,033

8

CKB^a,c

a,c

Creatine Kinase B

Genes for endometrial receptivity prediction

20,619,403

9

COX6C^b

b

Cytochrome C Oxidase Subunit 6C

Early embryo invasion

34,643,467

10

CREM^b

b

CAMP Responsive Element Modulator

Decidualization

21,159,852

11

CTSB^a

a

Cathepsin B

Embryonic development and Endometrial metamorphosis

9,310,336

12

DCN^a

a

Decorin

Receptivity associated gene

23,555,582

13

DLX6-AS1^a

a

DLX6 Antisense RNA 1

Dynamically expressed across the menstrual cycle; Regulation of trophoblast proliferation, migration and invasion in patients with pre-eclampsia

28,395,321;30,055,134

14

ELP3^b,d

b,d

Elongator Acetyltransferase Complex Subunit 3

Embryonic development

27,476,491

15

EPB41L2^a

a

Erythrocyte Membrane Protein Band 4.1 Like 2

Genes for endometrial receptivity prediction

33,910,562

16

FAP^a

a

Fibroblast Activation Protein Alpha

Receptivity associated gene

23,555,582

17

FN1^a,c

a,c

Fibronectin 1

FN1 isoforms and receptors associated with preimplantation embryo development

19,126,199

18

GABRP^a

a

Gamma-Aminobutyric Acid Type A Receptor Subunit Pi

Human early pregnancy trophoblast markers

32,359,161

19

GCH1^b

b

Embryo lethality

25,557,619

20

GRAMD1C^a,c

a,c

GRAM domain containing 1C

Receptivity associated gene

23,555,582

21

GSN^a

a

Gelsolin

Epithelial remodeling and embryo adhesion

29,763,784

22

HMGN1^a

a

High Mobility Group Nucleosome Binding Domain 1

Decidualization of uterine stromal cells

26,566,865

23

HNRNPH1^a

a

Heterogeneous Nuclear Ribonucleoprotein H1

Regulation of alternative splicing in germ cells; male infertility

35,739,118

24

IL1R1^a

a

Interleukin 1 Receptor Type 1

Receptivity associated gene

23,555,582

25

KIF12^a,c

a,c

Kinesin Family Member 12

Genes for endometrial receptivity prediction

33,910,562

26

NNMT^a,c

a,c

Nicotinamide N-Methyltransferase

Genes for endometrial receptivity prediction

33,910,562;20,619,403

27

NR1H3^a

a

Nuclear Receptor Subfamily 1 Group H Member 3

Human trophoblast invasion

15,242,983;18,276,933

28

NUCB2^b

b

Nucleobindin 2

Ovarian steroidogenesis and uterine function local regulator

30,981,497

29

OFD1^a

a

OFD1 Centriole And Centriolar Satellite Protein

Genes for endometrial receptivity prediction

33,910,562;20,619,403

30

PAX8^a

a

Paired Box 8

Receptivity associated gene

23,555,582

31

PDGFA^a,c

a,c

Platelet Derived Growth Factor Subunit A

Receptivity associated gene

25,429,785

32

PLXNB2^a

a

Plexin B2

Integrity of endometrial epithelium

25,237,006

33

POLD4^a

a

DNA Polymerase Delta 4, Accessory Subunit

Genes for endometrial receptivity prediction

20,619,403

34

POSTN^a

a

Periostin

Genes for endometrial receptivity prediction

20,619,403

35

SEC61A1^b

b

SEC61 Translocon Subunit Alpha 1

Decidualization

32,386,616

36

SECISBP2L^b

b

SECIS Binding Protein 2 Like

Embryonic development

35,210,313

37

SGK1^a

a

Serum/Glucocorticoid Regulated Kinase 1

Receptivity associated gene;maintenance of pregnancy

22,001,908;27,871,060

38

SH3YL1^a

a

SH3 And SYLF Domain Containing 1

Genes for endometrial receptivity prediction

33,910,562

39

SLC3A2^b

b

Solute Carrier Family 3 Member 2

Trophoblast differentiation

35,273,963

40

SYNE2^a,c

a,c

Spectrin Repeat Containing Nuclear Envelope Protein 2

Genes for endometrial receptivity prediction

20,619,403

41

TJP1^a

a

Tight Junction Protein 1

Human trophoblast proliferation and invasion

35,687,903

42

TSC2^b

b

TSC Complex Subunit 2

Follicular depletion and low fertility in female mice

22,128,018

43

UCA1^a

a

Urothelial Cancer Associated 1

Endometrial stromal cell autophagy and apoptosis

33,680,939