Fig. 6 | Scientific Reports

Fig. 6

From: New indole-linked 1,2,4-triazole derivatives as dual FAK inhibitors and apoptosis inducers targeting survival and migration in triple-negative breast cancer in-vitro

Fig. 6The alternative text for this image may have been generated using AI.

RT-qPCR results of FAK-related genes in breast cancer cell lines following treatment with the most active compounds. The figure shows the expression levels of PTK2 (FAK), PDL, VEGFR2, VIM, CCL5, CDH1, BCL2, and CASP3 in MDA-MB-231 and MCF-7 cells that were treated with the parent compound (2) and the selected active derivatives (3c, 4c, and 5c) alongside untreated controls. Relative expression is presented as fold change calculated by the comparative method (2−ΔΔCt) normalized to GAPDH. Log scale was used to visualize both up- and downregulation. Data are represented as mean ± SEM of three independent biological replicates (n = 3), *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.

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