Fig. 9 | Scientific Reports

Fig. 9

From: New indole-linked 1,2,4-triazole derivatives as dual FAK inhibitors and apoptosis inducers targeting survival and migration in triple-negative breast cancer in-vitro

Fig. 9The alternative text for this image may have been generated using AI.

The histopathological findings of the renal tissues of different experimental groups receiving a single intraperitoneal dose of the synthesized compound 4c (12.5, 25, and 50 mg/kg), as compared to the negative control group. Photomicrographs (a, b, c, and d) sections: in the kidney of negative control mice showing average glomeruli in number and size (yellow arrows), with intact proximal (blue arrow) and collecting tubules (red arrow) (H&E stain, upper photos X200, lower photos X400). Photomicrographs (e, f, g, and h): Sections in the kidney of 12.5 mg 4c-treated mice showing average number and size of glomeruli (yellow arrows), with mild irregularity in the contour as well as mild focal epithelial degeneration of proximal (blue arrow) and collecting tubules (red arrow). (H&E stain; upper left X200; upper right, lower left and lower right X400). Photomicrographs (i, j, k, and l): Sections in the kidney of 25 mg 4c-treated mice showing average number and size of glomeruli (yellow arrows), with mild irregularity in the contour as well as mild focal epithelial degeneration of proximal (blue arrow) and collecting tubules (red arrow). (H&E stain, upper left X200; upper right, lower left and lower right X400) Photomicrographs (m, n, o, and p): Sections in the kidney of 50 mg 4c-treated mice showing variable glomerular sizes with focal sclerosis (yellow arrows) with focal cortical inflammation (blue arrow) and medullary fibrosis (red arrow) (H&E stain, X400).

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