Table 3 Comparative table demonstrating the histopathological changes in the hepatic tissues of mice administrated a single intraperitoneal dose of the synthesized compound 4c (12.5, 25, and 50 mg/kg).
Group | Hepatic architecture | Hepatocyte changes | Inflammatory infiltration |
|---|---|---|---|
Negative Control | Regular lobular | Mild cloudy swelling | None |
12.5 mg/kg/one day | Preserved lobular | Moderate hydropic degeneration | Focal intra-lobular neutrophils |
25 mg/kg/one day | Preserved lobular | Moderate hydropic degeneration | Portal and intra-lobular neutrophils |
50 mg/kg/one day | Altered (focal necrosis) | Patchy necrosis | Dense intra-lobular neutrophils |
