Table 5 The biochemical changes in the serum biomarkers of hepatic function and renal inflammation in mice administrated a single intraperitoneal dose of the synthesized compound 4c (12.5, 25, and 50 mg/kg).

From: New indole-linked 1,2,4-triazole derivatives as dual FAK inhibitors and apoptosis inducers targeting survival and migration in triple-negative breast cancer in-vitro

Group

Serum AST

(IU/L)

Serum KIM-1

(ng/ml)

Negative control

77.97 ± 0.11 a

0.86 ± 0.01 a

12.5 mg

80.07 ± 0.06 b

3.38 ± 0.00 b

25 mg

86.16 ± 0.26 c

6.45 ± 0.01 c

50 mg

95.23 ± 0.29 d

9.72 ± 0.01 d

  1. Data are presented as mean ± standard error of the mean (SEM). Means with different superscripts (a: d) between groups are significantly different at p ≤ 0.05. Statistical analysis was carried out using one-way ANOVA followed by Duncan’s post-hoc test. AST: aspartate aminotransferase; KIM-1: Kidney-injury molecule 1.
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