Table 6 The oxidative status in the hepatic and renal tissues of mice administrated a single intraperitoneal dose of the synthesized compound 4c (12.5, 25, and 50 mg/kg).

From: New indole-linked 1,2,4-triazole derivatives as dual FAK inhibitors and apoptosis inducers targeting survival and migration in triple-negative breast cancer in-vitro

Group

Hepatic tissues

Renal tissues

MDA

(nmol/g)

NO

(µmol/g)

MDA

(nmol/g)

NO

(µmol/g)

Negative control

174.64 ± 0.02 a

104.95 ± 0.09 a

64.76 ± 0.08 a

72.78 ± 2.39 a

12.5 mg

175.61 ± 0.03 b

189.69 ± 0.09 b

74.37 ± 2.52 b

66.8 ± 1.14 a

25 mg

205.83 ± 0.00 c

284.05 ± 0.00 c

81.49 ± 1.06 c

95.13 ± 9.67 b

50 mg

236.161 ± 0.05 d

311.91 ± 0.00 d

83.21 ± 0.53 c

109.13 ± 6.75 b

  1. Data are presented as mean ± standard error of the mean (SEM). Means with different superscripts (a: d) between groups are significantly different at p ≤ 0.05. Statistical analysis was carried out using one-way ANOVA followed by Duncan’s post-hoc test. MDA: Malondialdehyde, NO: Nitric Oxide.
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