Fig. 3
From: Development and characterization of an inducible Tensin1 deficient transgenic murine model
Conditional TNS1 knockout does not result in vital organ histopathologic abnormalities 14 days after completion of tamoxifen treatment. Kidney tissue from non-treated (A), tamoxifen-treated B6.Tns1lox/lox (Tns1+/+) controls (B) and tamoxifen-treated RosaCre/+;Tns1lox/lox (Tns1-/-) mice (C) are depicted. Similarly, lung tissue from tamoxifen-treated B6.Tns1lox/lox (Tns1+/+) controls (E) and tamoxifen-treated RosaCre/+;Tns1lox/lox (Tns1-/-) mice (F) depicted and demonstrate minimal to mild interstitial infiltration of lymphocytes and plasma cells, alveolar histiocytosis, as well as multifocal perivascular leukocytic infiltrates (*), compared to non-treated lungs (D) which did not demonstrate these findings. Blue arrow marks an area of histiocytic and lymphoplasmacytic pleuritis with intralesional lipid material (F). (A–C) Scale bars = 2 mm for large scale images, 200 μm for the first set of insets (top), and 50 μm for the second set of insets (bottom). (D–F) Scale bars = 1 mm for large scale images (left column), 200 μm for the first set of insets (left column, top image in D; middle column in E; middle column, top image in F), and 50 μm for the second set of insets (left column, bottom image in D; far right column in E; middle column bottom image and far right column in F).
