Table 1 Pathological findings from Tns1+/+ and Tns1−/− mice treated with tamoxifen three, six and twelve months prior to analysis.
From: Development and characterization of an inducible Tensin1 deficient transgenic murine model
Organ | Pathologic finding | 3 months | 6 months | 12 months | |||
|---|---|---|---|---|---|---|---|
Tns1+/+ | Tns1−/− | Tns1+/+ | Tns1−/− | Tns1+/+ | Tns1−/− | ||
Lung | Alveolar histiocytosis | 1/2 | 4/4 | 0/3 | 2/4 | 0/1 | 0/4 |
Hemosiderosis | 1/2 | 3/4 | 0/3 | 1/4 | 0/1 | 0/4 | |
Lipid pneumonia | 0/2 | 0/4 | 0/3 | 1/4 | 0/1 | 0/4 | |
Kidney | Cysts | 0/1 | 0/5 | 0/3 | 0/4 | 0/1 | 0/4 |
Hydronephrosis | 0/1 | 1/5 | 0/3 | 0/4 | 0/1 | 0/4 | |
Peritoneum-Retroperitoneum (serosa) | Mild multifocal histiocytic and lymphoplasmacytic peritonitis-steatitis | 0/1 | 2/4 | 3/3 | 3/4 | 1/1 | 4/4 |
Incipient fibrosis | 1/1 | 4/4 | 1/3 | 2/4 | 1/1 | 1/4 | |
Endometrium | Endometrial hyperplasia | n/a | 0/3 | n/a | 1/2 | n/a | 2/3 |
Uterine tube or endometrial cysts | n/a | 2/3 | n/a | 1/2 | n/a | 1/3 | |
