Fig. 4 | Scientific Reports

Fig. 4

From: miR-320a enhances radiosensitivity in non-small cell lung cancer by targeting RAD51 and modulating ferroptosis via GPX4

Fig. 4The alternative text for this image may have been generated using AI.

RAD51 promotes radioresistance in NSCLC. (A) Comparison of RAD51 mRNA expression between NSCLC tumor tissues and adjacent normal tissues. (B) RAD51 mRNA and protein levels in BEAS-2B, A549, H1299, and H1975 cell lines (n = 3). (C) Kaplan–Meier analysis showing the association between RAD51 expression and overall survival in NSCLC patients. (D–F) Clonogenic survival of H1299 and H1975 cells exposed to increasing doses of radiation (0, 2, 4, 6, and 8 Gy). (G–I) Wound healing assay evaluating migration capacity of H1299 and H1975 cells at 48 h after irradiation. (J, K) Cell viability analysis using CCK-8 assay in irradiated H1299 and H1975 cells. (L) RAD51 protein expression in SD + PD vs. CR + PR patient subgroups. n = 60 NSCLC patients; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

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