Fig. 3

Kaplan–Meier survival curves for OS between GWMS groups in each RAS/BRAF genotype. OS according to the GWMS (LMCC or HMCC) in the RAS/BRAF wt group (A), the RAS mt group (B) and the mCRC subtypes (RAS/BRAF wt LMCC, RAS/BRAF wt HMCC, RAS mt mCRC, and BRAF mt mCRC) (C). Abbreviations: OS, overall survival; mt, mutant; wt, wild type; GWM, genome-wide methylation; LMCC, low-methylated colorectal cancer; HMCC, high-methylated colorectal cancer; CI, confidence interval; mCRC, metastatic colorectal cancer.