Table 2 GSEA results with MSI-H gene sets comparing HMCC (n = 22) vs. LMCC (n = 103) in patients with RAS/BRAF wild-type metastatic colorectal cancer.

From: RAS/BRAF wild-type metastatic high-methylated colorectal cancer has gene expression patterns related to MSI-H and BRAF V600E mutant: a translational research

Gene set name

ES

Normalized

ES

Nominal

P

FDR

Q-value

FWER

P

Brief description of gene set

WATANABE_COLON_CANCER_MSI_VS_MSS_UP

(C2.cgp)

0.645

2.005

0.002

0.197

0.189

Up-regulated genes discriminating between MSI and MSS colon cancers.

WATANABE_COLON_CANCER_MSI_VS_MSS_DN

(C2.cgp)

-0.670

-2.159

0.002

0.038

0.026

Down-regulated genes discriminating between MSI and MSS colon cancers.

64-gene signature for MSI phenotype (up in MSI-H)

0.604

1.68

0.01

0.01

0.01

Up-regulated genes discriminating between MSI and MSS colon cancers in Tian S et al 26.

64-gene signature for MSI phenotype (down in MSI-H)

-0.623

-1.87

0.002

0.001

0.001

Down-regulated genes discriminating between MSI and MSS colon cancers in Tian S et al 26.

  1. ES, enrichment score; FDR, false discovery rate; FWER, family-wise error rate; GSEA, gene set enrichment analysis; HMCC, high-methylated colorectal cancer; LMCC, low-methylated colorectal cancer; MSI, microsatellite instable; MSS, microsatellite stable.
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