Fig. 5
From: Glycan-binding properties of SARS-CoV-2 spike proteins: interactions with aminoglycoside antibiotics
Binding sites for tobramycin and sisomicin on the S protein predicted using in silico simulation. The protein surface is displayed as a semi-transparent surface, and the ligands are shown in stick representation or as a space-filling model. (a) and (c): binding state of tobramycin, (b) and (d): binding state of sisomicin, red: chain A, blue: chain B, green: chain C, orange dashed line: RBD. Purple circles show the tobramycin and sisomicin. Interaction analysis between ligands, (e) tobramycin (orange) and (f) sisomicin (orange), and the S protein. Blue lines: hydrogen bonds, dashed lines: van der Waals interaction between hydrophobic groups, yellow lines: salt bridges.
