Fig. 2 | Scientific Reports

Fig. 2

From: Admission blood pressure and mortality in acute aortic dissection: Southwest China multicenter retrospective cohort study

Fig. 2The alternative text for this image may have been generated using AI.Fig. 2The alternative text for this image may have been generated using AI.

Restricted Cubic Spline (RCS) Curves for the Association of Admission Blood Pressure with Short-term and Long-term Mortality. Adjusted Hazard Ratios (HRs) for the associations of admission systolic blood pressure (SBP) and diastolic blood pressure (DBP) with 30-day and 2-year all-cause mortality are shown via RCS models with 3 knots. The models were adjusted for: (1) Demographics: age, gender, type of AAD; (2) Medical history: Hypertension, coronary heart disease, type 2 diabetes mellitus, Marfan syndrome, heart bypass surgery, heart valve replacement; (3) Clinical biomarkers: NTproBNP and hsTNT at admission; (4) Presenting signs and symptoms at admission: Heart rhythm regularity, aortic aneurysm, thoracodynia, back pain, abdominal pain, syncope, pericardial effusion, and myocardial infarction. Figure 2 − 1 and 2–2 represent the dose-response relationship between admission SBP and DBP and the risk of 30-day mortality. Figure 2-3 and 2-4 represent the relationship between admission SBP and DBP and the risk of 2-year mortality. The solid blue lines indicate the estimated HRs, and the shaded light-blue areas represent the corresponding 95% confidence intervals (CIs). The pink histograms in the background reflect the density distribution of blood pressure values among the study participants. The horizontal dashed line is positioned at HR = 1.0 as the reference point. For 30-day mortality, the associations for SBP (P overall = 0.069) and DBP (P overall = 0.215) did not reach statistical significance. For 2-year mortality, significant non-linear associations were observed for both SBP (P overall = 0.009, P nonlinear = 0.008) and DBP (P overall = 0.020, P nonlinear = 0.005), indicating a J-shaped prognostic relationship.

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