Fig. 2

Overall representations of the proteomic data from the primary DCIS specimens. A) Heat map of unsupervised clustering of DCIS and benign epithelium ROIs clustered by antigen levels. Patient ER status, HER2 status and cohort are indicated on the top rows. For the benign epithelium, the ER and HER2 status refer to the co-existing DCIS. B) Heat map of the adjacent stroma and biopsy site ROIs clustered by antigen levels. ER and HER2 statuses refer to the co-existing DCIS. C) Volcano plot of unadjusted P-values showing differences between antigen levels in the DCIS versus benign epithelium. D) Volcano plot of unadjusted P-values showing differences between the stroma adjacent to the DCIS and identified biopsy sites. In C and D, points in red indicate antigens with FDR-adjusted P-values less than 0.05. The horizontal dashed lines indicate unadjusted P-values of 0.001.