Fig. 1 | Scientific Reports

Fig. 1

From: Exploring exosome-related genes as candidate biomarkers in primary immune thrombocytopenia through transcriptomics and preliminary experimental validation

Fig. 1The alternative text for this image may have been generated using AI.Fig. 1The alternative text for this image may have been generated using AI.Fig. 1The alternative text for this image may have been generated using AI.

(A)Volcano plot of differentially expressed genes; (B)Heatmap displaying the expression levels of the top 10 up- and down-regulated genes, with higher expression levels shown in red and lower levels in blue; (C)Box plot of seven significantly differentially expressed ERGs; (D)Distribution of ssGSEA scores for gene sets with differential directionality in disease samples versus healthy controls in the training set; (E)Cluster analysis dendrogram of samples from the training set GSE43179; (F)Screening of the soft-thresholding power for the WGCNA co-expression network (threshold β value set to 19). (G)Screening of the soft-thresholding power for the WGCNA co-expression network (threshold β value set to 19);(H–J)Module assignment of the gene co-expression network, distinguished by different colors, identifying a total of six co-expression modules; (K)Venn diagram showing the intersection of differentially expressed genes (DEGs) from the transcriptome and ERG module genes, resulting in 23 differentially expressed ERGs; (L)GO and KEGG enrichment analysis of the 23 candidate genes23. (M)GO and KEGG enrichment analysis of the 23 candidate genes2425; (N)Protein–protein interaction (PPI) network.

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