Fig. 6 | Scientific Reports

Fig. 6

From: Exploring exosome-related genes as candidate biomarkers in primary immune thrombocytopenia through transcriptomics and preliminary experimental validation

Fig. 6The alternative text for this image may have been generated using AI.

Validation of candidate genes expression levels in the discovery dataset and an independent clinical cohort. (A) Expression profiles of SLC39A14, HIBADH, GABARAPL1, and GSR in the discovery dataset GSE43179, consisting of 9 ITP patients and 10 healthy controls. (B–E) Relative mRNA expression levels of GABARAPL1, SLC39A14, GSR, and HIBADH in a de-novo clinical validation cohort (n = 20 ITP patients and n = 20 healthy controls), respectively. For the clinical cohort, relative quantification was performed using the 2 − ΔΔCt method, with GAPDH serving as the internal reference. Data are presented as mean ± SD. Statistical differences in the discovery dataset were assessed using the Wilcoxon rank-sum test, while an unpaired Student’s t-test was employed for inter-group comparisons in the clinical cohort. Statistical significance is indicated as follows: *P < 0.05, **P < 0.01, ns: not significant.

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