Fig. 2 | Scientific Reports

Fig. 2

From: Analysis of immune-related alterations in blood and spinal cord of canine degenerative myelopathy, a spontaneous model of amyotrophic lateral sclerosis

Fig. 2The alternative text for this image may have been generated using AI.

Results of real-time RT-PCR analysis of peripheral blood. (A) IL-10 and caspase 1 expression were significantly increased in DM dogs compared with healthy controls (p = 0.04 and p = 0.02, respectively). IL-18 and NLRP3 expression were increased in DM dogs compared with IVDH dogs (p = 0.02 and p = 0.03, respectively). Statistical comparisons among groups were performed using the Steel–Dwass test (DM: n = 12; healthy controls: n = 7; IVDH: n = 6). Each box represents the interquartile range, and the line within the box indicates the median. *p < 0.05. (B) Dot plot showing the relationship between CCR2 expression and months from disease onset. Correlations were assessed using Spearman’s rank correlation analysis (n = 19). The black bar represents the approximate line. CCR2 expression exhibited a moderate negative correlation with months from disease onset (p = 0.005, r = − 0.63). DM, degenerative myelopathy; IVDH, intervertebral disk herniation; IL, interleukin; TNFα, tumor necrosis factor α; CCR2, C–C motif chemokine receptor 2; NLRP3, nod-like receptor protein 3.

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