Fig. 4 | Scientific Reports

Fig. 4

From: GABARAPL1 is important for the activation of HRI during eIF2α phosphorylation-dependent stress response to sodium arsenite

Fig. 4

GABARAPL1 is a cofactor of HSP90 necessary for the activation of the HRI kinase during arsenite-mediated stress. In the absence of stress, HRI kinase is inactive and chaperoned by HSP90. Upon arsenite entry into cells, HRI undergoes trans-autophosphorylation, thereby becoming catalytically active. Under stress conditions, GABARAPL1 acts as a cofactor of HSP90, facilitating its interaction with HRI and promoting full kinase activation. Activated HRI phosphorylates eIF2α, leading to inhibition of cap-dependent mRNA translation and consequent SG formation.

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