Table 2 Baseline characteristics of patients with different metastatic status.

From: Differences in distant metastasis risk of breast cancer originating from various primary sites: a retrospective analysis based on the SEER database

Variables

Entire group N = 240,943

(N, %)

Distant metastasis group

Bone N = 5009

(N, %)

Brain N = 509

(N, %)

Liver N = 2178

(N, %)

Lung N = 2406

(N, %)

Survival months (M, 95%CI)

64.88 (39.09, 97.97)

32.22 (14.36, 53.59)

12.08 (3.37, 30.23)

25.21 (8.52, 46.80)

25.70 (9.60, 45.59)

Age at diagnosis

 

P = 0.298

P = 0.001

P = 0.000

P = 0.000

 < 72 years

207,063 (85.94)

4330 (86.4)

464 (91.2)

1941 (89.1)

2004 (83.3)

 ≥ 72 years

33,880 (14.06)

679 (13.6)

45 (8.8)

237 (10.9)

402 (16.7)

Race

 

P = 0.000

P = 0.002

P = 0.000

P = 0.000

 White

186,558 (77.43)

3773 (75.3)

382 (75.0)

1577 (72.4)

1700 (70.7)

 Black

26,564 (11.03)

775 (15.5)

80 (15.7)

384 (17.6)

465 (19.3)

 Othera

27,821 (11.54)

461 (9.2)

47 (9.2)

217 (10.0)

241 (10.0)

Marital status

 

P = 0.000

P = 0.000

P = 0.000

P = 0.000

 Unmarriedb

89,207 (37.02)

2394 (47.8)

259 (50.9)

1012 (46.5)

1224 (50.9)

 Married

141,957 (58.92)

2386 (47.6)

225 (44.2)

1065 (48.9)

1059 (44.0)

 Unknown

9779 (4.06)

229 (4.6)

25 (4.9)

101 (4.6)

123 (5.1)

Year of diagnosis

 

P = 0.183

P = 0.978

P = 0.403

P = 0.515

 2010–2014

103,521 (42.96)

2106 (42.0)

219 (43.0)

955 (43.8)

1018 (42.3)

 2015–2019

137,422 (57.04)

2903 (58.0)

290 (57.0)

1223 (56.2)

1388 (57.7)

Breast subtype

 

P = 0.000

P = 0.000

P = 0.000

P = 0.000

 HR + /HER2-

169,170 (70.21)

3140 (62.7)

213 (41.8)

855 (39.3)

1207 (50.2)

 HR + /HER2 + 

29,197 (12.12)

962 (19.2)

98 (19.3)

566 (26.0)

463 (19.2)

 HR-/HER2 + 

12,015 (4.99)

387 (7.7)

78 (15.3)

395 (18.1)

271 (11.3)

 HR-/HER2-

30,561 (12.68)

520 (10.4)

120 (23.6)

362 (16.6)

465 (19.3)

Primary site

 

P = 0.000

P = 0.000

P = 0.000

P = 0.000

 UOQ

94,769 (39.33)

1819 (36.3)

183 (36.0)

837 (38.4)

860 (35.7)

 LIQ

15,073 (6.26)

278 (5.6)

27 (5.3)

108 (5.0)

139 (5.8)

 UIQ

35,705 (14.82)

503 (10.0)

49 (9.6)

192 (8.8)

239 (9.9)

 LOQ

20,836 (8.65)

400 (8.0)

47 (9.2)

184 (8.4)

205 (8.5)

 Axillary tail

1210 (0.50)

39 (0.8)

3 (0.6)

13 (0.6)

22 (0.9)

 Overlapping

61,558 (25.55)

1526 (30.5)

158 (31.0)

669 (30.7)

753 (31.3)

 TCNPc

11,792 (4.89)

444 (8.9)

42 (8.3)

175 (8.0)

188 (7.8)

Laterality

 

P = 0.000

P = 0.941

P = 0.002

P = 0.000

 Left

121,959 (50.62)

2553 (51.0)

254 (49.9)

1095 (50.3)

1236 (51.4)

 Right

118,976 (49.38)

2453 (49.0)

255 (50.1)

1082 (49.7)

1168 (48.5)

 Bilateral

8 (0.00)

3 (0.1)

0 (0.0)

1 (0.0)

2 (0.1)

Grade

 

P = 0.000

P = 0.000

P = 0.000

P = 0.000

 I

52,259 (21.69)

356 (7.1)

20 (3.9)

75 (3.4)

115 (4.8)

 II

100,457 (41.69)

2310 (46.1)

176 (34.6)

775 (35.6)

870 (36.2)

 III/IV

88,227 (36.62)

2343 (46.8)

313 (61.5)

1328 (61.0)

1421 (59.1)

Tumor size

 

P = 0.000

P = 0.000

P = 0.000

P = 0.000

 < 29 mm

187,432 (77.79)

1426 (28.5)

144 (28.3)

608 (27.9)

503 (20.9)

 ≥ 29 mm

53,511 (22.21)

3583 (71.5)

365 (71.7)

1570 (72.1)

1903 (79.1)

Node status

 

P = 0.000

P = 0.000

P = 0.000

P = 0.000

 Negative

130,188 (54.03)

424 (8.5)

46 (9.0)

174 (8.0)

194 (8.1)

 Positive

100,564 (41.74)

2706 (54.0)

223 (43.8)

1197 (55.0)

1209 (50.2)

 Unknown

10,191 (4.23)

1879 (37.5)

240 (47.2)

807 (37.1)

1003 (41.7)

Surgery

 

P = 0.000

P = 0.000

P = 0.000

P = 0.000

 Yes

229,173 (95.12)

1535 (30.6)

93 (18.3)

610 (28.0)

652 (27.1)

 No/Unknown

11,770 (4.88)

3474 (69.4)

416 (81.7)

1568 (72.0)

1754 (72.9)

Radiotherapy

 

P = 0.000

P = 0.000

P = 0.000

P = 0.000

 Yes

146,392 (60.76)

2031 (40.5)

349 (68.6)

583 (26.8)

661 (27.5)

 No/Unknown

94,551 (39.24)

2978 (59.5)

160 (31.4)

1595 (73.2)

1745 (72.5)

 Chemotherapy

 

P = 0.000

P = 0.000

P = 0.000

P = 0.000

 Yes

111,758 (46.38)

3362 (67.1)

335 (65.8)

1718 (78.9)

1702 (70.7)

 No/unknown

129,185 (53.62)

1647 (32.9)

174 (34.2)

460 (21.1)

704 (29.3)

  1. aIncluding American Indian/Alaskan native, Asian/Pacific Islander, and others-unspecified.
  2. bIncluding divorced, separated, single (never married), unmarried, domestic partner, and widowed.
  3. cIncluding the central and nipple portion.
  4. *P values indicated differences in the distribution of patient characteristics between the entire cohort and each distant metastasis subgroup.
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