Fig. 1 | Scientific Reports

Fig. 1

From: Numb mitigates intestinal epithelial cell senescence induced by radiation through a PLK1-dependent pathway

Fig. 1

Inhibiting Numb expression exacerbated radiation-induced intestinal barrier injury and reduced survival. (A) Immunohistochemistry was used to assess Numb expression in the intestinal mucosa. (B) Kaplan‒Meier survival analysis of mice following exposure to 13 Gy of whole abdominal irradiation (WAI). n = 15 mice for control group and 10 mice for Numb antisence group. (C) Representative images depicting E-cadherin and F-actin immunofluorescence staining in the intestinal mucosa at 7 days post-WAI. Scale bar = 50 μm. (D) Weight loss of irradiated mice after 13 Gy WAI. n = 10 mice for both control group and Numb antisence group. (E) Serum levels of FD40 in mice from different groups. n = 3 mice in each group. (F) Serum concentrations of DAO in mice from different groups. n = 3 mice in each group. *P < 0.05, **P < 0.01.

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