Table 1 Characteristics of the study population in total and divided by high or low COL1α1 levels (below or above median level).

From: Circulating type I collagen pro-α1 chain is inversely associated with the presence of coronary atherosclerosis in a Swedish middle-aged population

COL1α1 (pg/mL)

Total (n = 1078)

Low COL1α1 (n = 539)

High COL1α1 (n = 539)

p

6070 (4430)

4250 (1880)

8680 (4010)

< 0.001

Characteristics

    

Age, years

57.2 (7.5)

57.2 (7.7)

57.1 (7.2)

0.1

Women, n (%)

535 (49)

199 (38)

330 (62)

< 0.001

Current smoker, n (%) a

75 (6.9)

41 (7.7)

33 (6.2)

0.3

Waist-hip ratio

0.91 (0.13)

0.93 (0.12)

0.88 (0.12)

< 0.001

Diabetes, n (%) a

86 (8.0)

61 (12)

22 (4.1)

< 0.001

Anti-hypertensive medication, n (%) a

190 (18)

115 (22)

71 (13)

< 0.001

Office SBP, mmHg

129 (23)

131 (23

128 (24)

0.007

Office DBP, mmHg

82 (14)

83 (14)

81 (13)

0.06

Lipid-lowering medication, n (%) a

74 (6.9)

51 (9.6)

22 (4.1)

< 0.001

Previous CVD, n (%) a

19 (1.8)

11 (2.1)

8 (1.5)

0.5

Biochemical analyses

Total cholesterol, mmol/L

5.4 (1.4)

5.4 (1.5)

5.4 (1.4)

0.048

Triglycerides, mmol/L

1.0 (0.74)

1.1 (0.71)

0.96 (0.68)

< 0.001

HDL cholesterol, mmol/L

1.6 (0.6)

1.5 (0.6)

1.7 (0.7)

< 0.001

LDL cholesterol, mmol/L

3.2 (1.2)

3.3 (1.0)

3.2 (1.3)

0.9

Creatinine, µmol/L

81 (18)

82 (19)

79 (20)

< 0.001

eGFR, mL/min/1.73 m2

74 (12)

74 (12)

75 (12)

1.0

Glucose, mmol/L

5.6 (0.7)

5.7 (0.8)

5.5 (0.7)

< 0.001

HbA1c, mmol/mol

35 (4)

35 (5)

34 (3)

0.01

CRP, mg/L

0.9 (1.5)

1.0 (1.3)

0.90 (1.4)

0.005

IL-6, pg/mL

1.09 (0.75)

1.06 (0.78)

1.02 (0.75)

0.03

MMP-9, pg/mL

54,700 (37000)

53,600 (38000)

56,200 (37000)

0.04

Measures of coronary atherosclerosis, n (%)

Calcium score ≥ 100

117 (11)

67 (13)

49 (9.4)

0.06

Calcium score ≥ 400

36 (3.4)

19 (3.7)

16 (3.1)

0.6

Any stenosis

342 (34)

186 (38)

153 (31)

0.02

Any stenosis ≥ 50%

45 (4.5)

33 (6.7)

12 (2.4)

0.001

Any calcified plaque

319 (32)

172 (35)

145 (29)

0.05

Any non-calcified plaque

39 (3.9)

29 (5.9)

9 (1.8)

< 0.001

SIS > 0

342 (34.1)

186 (37.7)

153 (30.8)

0.02

SIS ≥ 4

78 (7.8)

49 (9.9)

28 (5.6)

0.01

  1. a Data based on questionnaires. Missing values imputed as “no”.
  2. Data presented as median (IQR) for continuous variables and as frequencies (%) for categorical variables. P-values calculated with Mann-Whitney U for group comparison of continuous variables and with the Chi-squared test for categorical variables.
  3. COL1α1 = type I collagen pro-α1 chain; SBP = systolic blood pressure; DBP = diastolic blood pressure; HDL = high density lipoprotein; CRP = C-reactive protein; IL-6 = interleukin-6; LDL = low-density lipoprotein; HbA1c = hemoglobin A1c; eGFR = estimated glomerular filtration rate; SIS = segmental involvement score.
Back to article page