Table 2 Titers and prevalences of the herpesviruses included in the study and their comparisons among the MS cohorts and healthy controls.

From: Differential distribution of antiviral serology across multiple sclerosis phenotypes and its implications for disease pathogenesis

 

PPMS

RRMS

SPMS

HC

PP vs. RR

PP vs. SP

PP vs. HC

RR vs. SP

RR vs. HC

SP vs. HC

 

EBNA-1 IgG

21.4 AU

24.2 AU

24.4 AU

20.8 AU

0.0004

0.00003

n.s.

n.s.

n.s.

n.s.

p value*

149/156

(95.5%)

227/243

(93.4%)

72/76

(94.7%)

137/156

(87.8%)

n.s.

n.s.

n.s.

n.s.

n.s.

n.s.

p value**

O.R. (95% CI)***

EBV VCA IgG

49.9 AU

47.6 AU

50.5 AU

44.0 AU

n.s.

n.s.

0.00004

n.s.

0.00003

0.00004

p value*

151/158

(95.6%)

252/257

(98.1%)

74/75

(98.7%)

153/158

(96.8%)

n.s.

n.s.

n.s.

n.s.

n.s.

n.s.

p value**

O.R. (95% CI)***

CMV IgG

30.0 AU

16.0 AU

24.5 AU

25.8 AU

0.000002

n.s.

n.s.

n.s.

0.002

n.s.

p value*

116/158

(73.4%)

118/211

(55.9%)

49/72

(68.1%)

101/132

(76.5%)

0.0006

2.2 (1.4–3.4)

n.s.

n.s.

n.s.

0.0001

2.6 (1.6–4.2)

n.s.

p value**

O.R. (95% CI)***

HHV-6 IgG

25.7 AU

30.5 AU

26.9 AU

32.5 AU

n.s.

n.s.

n.s.

n.s.

n.s.

n.s.

p value*

124/139

(89.2%)

218/246

(88.6%)

64/74

(86.5%)

142/156

(91.0%)

n.s.

n.s.

n.s.

n.s.

n.s.

n.s.

p value**

O.R. (95% CI)***

HHV-6 IgM

3.8 AU

5.0 AU

3.6 AU

5.2 AU

n.s.

n.s.

n.s.

0.002

n.s.

n.s.

p value*

24/147

(16.3%)

39/252

(15.5%)

3/74

(4.1%)

30/151

(19.9%)

n.s.

n.s.

n.s.

n.s.

n.s.

n.s.

p value**

O.R. (95% CI)***

  1. AU: artificial units (median values); those doubtful values, between 9–11 AU, where excluded. n.s.: not significant. Only significant values after Bonferroni correction are shown (p < 0.0083). * p values were calculated from Mann–Whitney U-test. ** p values were calculated from Chi-square test/ Fisher’s exact test. *** Odds Ratios with the 95% Confidence Intervals.