Fig. 5
From: A d-dimer and ADAMTS8 based multi-marker score for the diagnosis of acute aortic dissection
Validation of the ADAMTS8 levels and the multi-marker score in the independent validation set. (A, B) ADAMTS8 levels and multi-marker scores were significantly elevated in AAD group compared with healthy controls (ADAMTS8, median [IQR]: 913.33 [733.86, 1067.66] pg/mL vs. 504.03 [394.40, 838.89] pg/mL, P < 0.0001). (C) ROC curve of ADAMTS8 for differentiating AAD from healthy controls (AUC = 0.788, 95% CI: 0.733–0.842). (D) ROC curve analysis of the multi-marker score for discriminating AAD from healthy controls (AUC = 0.928, 95% CI: 0.897–0.959). (E, F) ADAMTS8 levels and multi-marker scores were significantly higher in AAD patients than in non-AAD acute chest pain patients (ADAMTS8, median [IQR]: 913.33 [733.86, 1067.66] pg/mL vs. 626.30 [462.80, 732.34] pg/mL, P < 0.0001). (G) ROC curve of ADAMTS8 for discriminating AAD from non-AAD acute chest pain patients (AUC = 0.788, 95% CI: 0.732–0.843). (H) ROC curve of ADAMTS8 for discriminating AAD from non-AAD acute chest pain patients (AUC = 0.887, 95% CI: 0.848–0.926). (I, J) ADAMTS8 levels and multi-marker scores were significantly higher in the AAD group than in AMI patients. (ADAMTS8, median [IQR]: 913.33 [733.86, 1067.66] pg/mL vs. 504.03 [394.40, 838.89] pg/mL, P < 0.0001). (K, L) For differentiating AAD from AMI, ADAMTS8 had an AUC of 0.803 (95% CI: 0.747–0.859), while the multi-marker score reached an AUC of 0.913 (95% CI: 0.877–0.949). (M, N) ADAMTS8 levels and multi-marker scores were significantly higher in the AAD group than in PE patients. (ADAMTS8, median [IQR]: 913.33 [733.86, 1067.66] pg/mL vs. 660.48 [524.13, 760.44] pg/mL, P < 0.0001). (O, P) For differentiating AAD from PE, ADAMTS8 had an AUC of 0.752 (95% CI: 0.671–0.833), while the multi-marker score reached an AUC of 0.825 (95% CI: 0.756–0.894).
