Fig. 3: Comparison of burden of CH pain and MS pain.

a Global burden (total number of annual person-years) for cluster headache and multiple sclerosis, assuming a skew-normal distribution for MS pain with median = 3.5, mean = 2.0, and SD = 1.8. b Intensity-adjusted global burden assuming the pain is weighted exponentially (proportional to x2). c Intensity weight transformation for which the total global pain burden of CH is larger than that of MS (approximately ~x2).