Nat. Methods https://doi.org/10.1038/s41592-018-0008-0 (2018).

A new microscope from Alipasha Vaziri’s lab at Rockefeller University in New York is taking volumetric neuronal image deeper into the brain of freely moving mice. The device, dubbed miniLFM, combines three previous technologies to enable the feat: light field microscopy, to capture volumetric data with minimal phototoxicity; a seeded iterative demixing (SID) computational strategy, to overcome light scattering in deeper tissue; and modified miniscopes, to reduce the overall weight. Adult mice could carry the head-mounted devices without ill effect, and the researchers were able to record neuronal activity up to 360 µm deep in the hippocampus of freely moving animals.