The mammalian gut microbiota confers colonization resistance against pathogenic bacteria. Specific pathogen-free C57BL/6 mice from different vendors are variably resistant to oral non-typhoidal Salmonella infection. New work shows that differences in endogenous Enterobacteriaceae determine this phenotypic variability.
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References
Barthel, M. et al. Infect. Immun. 71, 2839–2858 (2003).
Stecher, B. et al. PLoS Biol. 5, 2177–2189 (2007).
Rivera-Chávez, F. & Bäumler, A. J. Annu. Rev. Microbiol. 69, 31–48 (2015).
Rivera-Chávez, F. et al. Cell Host Microbe 19, 443–454 (2016).
Brugiroux, S. et al. Nat. Microbiol. 2, 16215 (2016).
Litvak, Y. et al. Cell Host Microbe 25, 128–139.e5 (2019).
Velazquez, E. M. et al. Nat. Microbiol. 4, 1057–1064 (2019).
Herp, S. et al. Cell Host Microbe 25, 681–694.e8 (2019).
Beura, L. K. et al. Nature 532, 512–516 (2016).
Rosshart, S. P. et al. Cell 171, 1015–1028 (2017).
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Hapfelmeier, S. Outrunning Salmonella – the role of endogenous Enterobacteriaceae in variable colonization resistance. Lab Anim 48, 203–204 (2019). https://doi.org/10.1038/s41684-019-0327-5
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DOI: https://doi.org/10.1038/s41684-019-0327-5
