Fig. 1: Efficacy and clinical tolerance of sustained antibiotic treatment in ferrets.
NW specimens were collected for aerobic bacterial culture before first antibiotic treatment a, Relative abundances of the top ten taxa identified by MALDI-TOF were normalized per ferret. Gram-positive and Gram-negative are abbreviated as g+ and g–, respectively. b, Corresponding bacterial loads are displayed as geometric means ± s.d. (day (D)0). Ferrets then received injectable antibiotics (SQ), oral antibiotics (PO) or mock treatment, and bacterial loads were assessed at the indicated time points (D0, D7 and D14). Changes in bacterial loads were analyzed by multiple comparisons after repeated-measures two-way ANOVA. Bars represent geometric mean with geometric s.d. from day 0, 7 or 14 post-treatment. n = 6 ferrets per group. Limit of detection, 10 CFU. n.s., not significant. *P ≤ 0.05.
