Fig. 1: Consumption rate determination for steady body weight and complete consumption of provided 93M in B6129SF1/J mice. | Lab Animal

Fig. 1: Consumption rate determination for steady body weight and complete consumption of provided 93M in B6129SF1/J mice.

From: Diet gel-based oral drug delivery system for controlled dosing of small molecules for microglia depletion and inducible Cre recombination in mice

Fig. 1

a, Experimental design of feeding groups receiving either 6, 8 or 10 g of drug-free 93M every 24 h over 14 days. n = 6 mice (3 males, 3 females) per feeding group. Unconsumed 93M (g) and body weight (g) were measured after each 24 h feeding cycle, including a body weight measurement before (day −1) and after (day 0) an initial fasting period of 16 h. b, Unconsumed 93M (g) after each feeding cycle per feeding group and sex (n = 3). The # symbol indicates data points at 0 g of unconsumed 93M. c,d, Temporal body weight measurements normalized and compared with the post-fasting body weight (day 0) in males (c) and females (d) (n = 3). Two-way ANOVA with Dunnett’s multiple comparisons tests were performed for c and d. The results are shown as mean ± s.e.m (b,c,d). Significance levels: *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001.

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