Fig. 2: Illustration of weight threshold impact on treatment comparisons.
From: Exploration of refined humane endpoints for melioidosis in BALB/c mice
a–c, A comparison of co-trimoxazole and finafloxacin treatment (study 1 data only) when there is no change in the weight threshold, that is, using the original study conditions in which no body weight threshold was in place (a); when using a percentage weight loss threshold of 25% (b); and when using a percentage weight loss threshold of 20% (c). Lines represent Kaplan–Meier survival estimates with 95% CIs (corresponding shaded areas). P values were generated using log-rank tests between groups: co-trimoxazole (n = 45) versus finafloxacin (n = 45) in each case.
