Fig. 5: Optimization illustration of alternative humane endpoints on accuracy and time in study.
From: Exploration of refined humane endpoints for melioidosis in BALB/c mice
a,b, Specificity plotted against ‘median days saved’ (a) and ‘median sign-days saved’ (b), across the humane endpoints evaluated and derived according to weight loss threshold values, grouped by total signs and average total signs threshold values (data from all four studies). Each point represents an alternative humane endpoint, color-coded by clinical threshold value and corresponding to weight thresholds ranging from 23% to 28%. Labeled points illustrate the 25% weight threshold values, which lie in the middle of each color-coded group.
