Table 2 Morphometric variables associated with outcome after primary DCIS diagnosis. Odds ratios (OR) and 95%CIs from the univariate linear regression models according iIBC status
From: A morphometric signature to identify ductal carcinoma in situ with a low risk of progression
Measurements | Parameter | abbreviation | OR | 95%CI |
|---|---|---|---|---|
DCIS geometrics | ||||
area of DCIS ducts | Kernel density | area-[kd] | 0.81 | (0.72–0.9) |
standard deviation | area-[sd] | 0.8 | (0.72–0.9) | |
total | area-[to] | 0.82 | (0.73–0.92) | |
estimated radius of DCIS ducts | Kernel density | radius-[kd] | 0.82 | (0.73–0.92) |
mean | radius-[me] | 0.82 | (0.73–0.92) | |
range | radius-[rg] | 0.81 | (0.72–0.91) | |
total | radius-[to] | 0.86 | (0.77–0.96) | |
perimeter of DCIS ducts | Kernel density | perimeter-[kd] | 0.84 | (0.75–0.94) |
mean | perimeter-[me] | 0.83 | (0.74–0.93) | |
median | perimeter-[md] | 0.86 | (0.77–0.97) | |
range | perimeter-[rg] | 0.82 | (0.73–0.92) | |
skewness | perimeter-[sk] | 0.88 | (0.79–0.99) | |
roundness of DCIS ducts | mode | roundness-[mo] | 1.13 | (1.01–1.26) |
range | roundness-[rg] | 0.85 | (0.76–0.95) | |
skewness | roundness-[sk] | 0.82 | (0.74–0.92) | |
circular shape of DCIS ducts | range | shape-[rg] | 0.82 | (0.73–0.92) |
standard deviation | shape-[sd] | 0.82 | (0.73–0.91) | |
skewness | shape-[sk] | 1.13 | (1–1.26) | |
DCIS cells geometrics | ||||
number of cells per DCIS duct area | Kernel density | cellularity-[kd] | 1.14 | (1.01–1.27) |
number of cells per DCIS duct | Kernel density | cells/duct-[kd] | 0.8 | (0.71–0.89) |
median | cells/duct-[md] | 0.81 | (0.72–0.91) | |
standard deviation | cells/duct-[sd] | 0.81 | (0.72–0.9) | |
total | cells/duct-[to] | 0.83 | (0.74–0.93) | |
variation of cell nucleus size in a DCIS duct | skewness | nuc size var-[sk] | 1.13 | (1.01–1.27) |
total | nuc size var-[to] | 0.88 | (0.78–0.99) | |
DCIS spatial arrangement | ||||
maximal distances between DCIS ducts | standard deviation | max duct dist-[sd] | 0.85 | (0.76–0.95) |
total | min duct dist-[to] | 0.87 | (0.78–0.98) | |
single-cell spatial arrangement | ||||
maximal cell distances within DCIS ducts | standard deviation | max cell dist-[sd] | 0.89 | (0.79–0.99) |
Kernel density | min cell dist-[kd] | 1.13 | (1.01–1.27) | |
microenvironment | ||||
DCIS/stroma | ratio | DCIS/stroma-(r) | 0.81 | (0.73–0.91) |
